NFL Week 1 Best Game to Bet: Los Angeles Rams vs. Buffalo Bills

Author: Sasha Yodashkin | Fact checker: Tommi Valtonen · Updated: · Ad Disclosure
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NFL football makes its return this week, and the first game of the season pits the Super Bowl LVI champion Los Angeles Rams against this year’s Super Bowl betting favorite Buffalo Bills. There’s a full Sunday of NFL Week 1 action to bet on as well, but we’ll focus specifically on the Rams and Bills, who are scheduled to kick off at 8:20 p.m. EDT on Thursday from SoFi Stadium in Inglewood, CA.

There’s no shortage of ways to bet on the first game of the NFL season if you’re located in a state where online and mobile sportsbooks such as Caesars Sportsbook operate. Those states include Arizona, Colorado, Connecticut, Illinois, Indiana, Iowa, Louisiana, Michigan, New Jersey, New York, Ohio, Pennsylvania, Tennessee, Virginia, West Virginia, Wyoming and, as of last week, Kansas. Leading NFL betting sites include DraftKings, FanDuel, BetMGM, WynnBET, BetRivers, and PointsBet. In addition to line shopping among these various sportsbooks for the most favorable odds throughout the NFL season, downloading multiple mobile sportsbooks will also allow you to take advantage of the generous welcome offers and promotions unique to each of these betting platforms.

You can stick with the basics and bet on the moneyline (Bills -134), spread (Bills -2.5) or combined point total (over/under 52.5), or incorporate prop bets along with some of these elements in one of Caesars’ Same Game Parlays. Some of the many props available in Same Game Parlays (or as standalone bets themselves), include a touchdown at any time for Cooper Kupp (-155), Cam Akers (+110), Stefon Diggs (+125), Devin Singletary (+140), Gabriel Davis (+145), Allen Robinson (+150) and other skill players on these two high-powered offenses, though you should make sure not to forget that both teams also boast stout defenses before betting on too many players to score. Other popular prop bets include over/unders on individual rushing, receiving and passing yard totals, as well as alternate totals. For example, the over/under for Josh Allen’s passing yards is set at 274.5 yards, but you can wager on him to top any number of passing yards from 200 (-1100) to 350 (+520) at 25-yard intervals.

author

Sasha has been writing about sports since 2014. He's a huge New York sports fan and has written for multiple sports publications, such as RotoWire, Yahoo Sports, and Tipico Sportsbook.

In addition to sports writing, Sasha, a Binghamton University graduate, has been featured on Yahoo! Finance and multiple local television networks.